The Big South basketball slate on Friday is sure to please. The matchups include the Winthrop Eagles playing the Louisville Cardinals at KFC Yum! Center, and there are picks against the spread available in this article.

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Big South Picks ATS Today

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Pick: Longwood +6.5 vs. UAB

• Matchup: Longwood Lancers vs. UAB Blazers
• Projected Favorite & Spread: Longwood by 3 points (Bet on BetMGM)
• Spread: UAB -6.5
• Time: 12:30 PM ET
• Date: November 22
• TV Channel: ESPN Networks

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Pick: Presbyterian +6.5 vs. Youngstown State

• Matchup: Presbyterian Blue Hose vs. Youngstown State Penguins
• Projected Favorite & Spread: Youngstown State by 4.2 points (Bet on BetMGM)
• Spread: Youngstown State -6.5
• Time: 3:30 PM ET
• Date: November 22
• TV Channel: ESPN+
• Live Stream: ESPN+

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Pick: Winthrop +16.5 vs. Louisville

• Matchup: Winthrop Eagles at Louisville Cardinals
• Projected Favorite & Spread: Louisville by 14.5 points (Bet on BetMGM)
• Spread: Louisville -16.5
• Time: 7:00 PM ET
• Date: November 22
• TV Channel: ACC Network Extra

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